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Nickel-Mediated Cycloaddition by Two Sequential C[BOND]H Activations


  • The NIGMS, the NSF, the DOE, and Merck are gratefully acknowledged for financial support.


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Double the fun: The future of cross-coupling chemistry lies in the development of cleaner synthetic methods for carbon–carbon bond formation. A recent advancement in the field of nickel-catalyzed C(sp2)–C(sp3) cross-couplings (see scheme) via two C[BOND]H activations represents a major step forward.