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Supramolecular Nanofibers and Hydrogels of Nucleopeptides


  • This work was partially supported by NIH (R01CA142746), NSF (DMR 0820492), a HFSP grant (RGP0056/2008), and start-up grant from Brandeis University. The images were taken at Brandeis EM facilities.


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Watson–Crick interactions: The conjugation of nucleobases (B=thymine, adenine, cytosine, and guanine; see picture) with small peptides affords a novel kind of supramolecular nanofibers and hydrogelators, which exhibit a high biocompatibility and biostability and are regarded as promising new biomaterials.