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Electrochemical Control of Growth Factor Presentation To Steer Neural Stem Cell Differentiation

Authors

  • Dr. Anna Herland,

    Corresponding author
    1. Cell and Molecular Biology, Karolinska Institute von Eulers väg 3, 17177 Solna (Sweden)
    • Cell and Molecular Biology, Karolinska Institute von Eulers väg 3, 17177 Solna (Sweden)
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  • Kristin M. Persson,

    1. Department of Science and Technology, Organic Electronics, Linköping University, Bredgatan 33, 601 74 Norrköping (Sweden)
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    • These authors contributed equally to this work.

  • Vanessa Lundin,

    1. Cell and Molecular Biology, Karolinska Institute von Eulers väg 3, 17177 Solna (Sweden)
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    • These authors contributed equally to this work.

  • Prof. Mats Fahlman,

    1. Department of Physics, Chemistry and Biology, Linköping University, 58183 Linköping (Sweden)
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  • Prof. Magnus Berggren,

    1. Department of Science and Technology, Organic Electronics, Linköping University, Bredgatan 33, 601 74 Norrköping (Sweden)
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  • Dr. Edwin W. H. Jager,

    1. Department of Science and Technology, Organic Electronics, Linköping University, Bredgatan 33, 601 74 Norrköping (Sweden)
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  • Dr. Ana I. Teixeira

    Corresponding author
    1. Cell and Molecular Biology, Karolinska Institute von Eulers väg 3, 17177 Solna (Sweden)
    • Cell and Molecular Biology, Karolinska Institute von Eulers väg 3, 17177 Solna (Sweden)
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  • We thank Prof. Ola Hermanson (Karolinska Institutet) and group members for use of cell culture facilities and assistance. We would like to acknowledge funding from the Swedish Research Council (VR) and the Swedish Foundation for Strategic Research (SSF; the OBOE center). V.L. was supported by a KID fellowship from the Karolinska Institute and A.H. was supported by a postdoctoral grant from VR. M.B. wishes to thank the Önnesjö foundation and Linköping University for financial support.

Abstract

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Let it grow: The conjugated polymer poly(3,4-ethylenedioxythiophene) (PEDOT) was synthesized with heparin as the counterion to form a cell culture substrate. The surface of PEDOT:heparin in the neutral state associated biologically active growth factors (see picture). Electrochemical in situ oxidation of PEDOT during live cell culture decreased the bioavailability of the growth factor and created an exact onset of neural stem cell differentiation.

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