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Keywords:

  • acidity;
  • antitumor agents;
  • drug delivery;
  • micelles;
  • reduction
Thumbnail image of graphical abstract

On the double: A highly packed interlayer-crosslinked micelle (HP-ICM) with pH and reduction sensitivity was developed for targeted drug release (see picture; DTT=dithiothreitol, red circles=doxorubicin). The HP-ICM suppresses drug leakage in blood circulation while rapidly releasing drug inside lysosomes of cancer cells. Biological studies revealed the potential of the dual-sensitive HP-ICM in cancer treatment.