These authors contributed equally to this work.
Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release†
Article first published online: 5 SEP 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 40, pages 9404–9408, September 26, 2011
How to Cite
Dai, J., Lin, S., Cheng, D., Zou, S. and Shuai, X. (2011), Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release. Angew. Chem. Int. Ed., 50: 9404–9408. doi: 10.1002/anie.201103806
This research was supported by the Natural Science Foundation of China (50830107, 20974129, U1032002) and Guangdong (9351027501000003), the 863 Programs (2009AA03Z310) and Projects for the Creation of Significant New Drugs Programs (2009ZX09501-023) of the Ministry of Science and Technology of China.
- Issue published online: 21 SEP 2011
- Article first published online: 5 SEP 2011
- Manuscript Revised: 22 JUL 2011
- Manuscript Received: 4 JUN 2011
- Natural Science Foundation of China. Grant Numbers: 50830107, 20974129, U1032002
- Guangdong. Grant Number: 9351027501000003
- Ministry of Science and Technology of China
- antitumor agents;
- drug delivery;
On the double: A highly packed interlayer-crosslinked micelle (HP-ICM) with pH and reduction sensitivity was developed for targeted drug release (see picture; DTT=dithiothreitol, red circles=doxorubicin). The HP-ICM suppresses drug leakage in blood circulation while rapidly releasing drug inside lysosomes of cancer cells. Biological studies revealed the potential of the dual-sensitive HP-ICM in cancer treatment.