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Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release

Authors

  • Dr. Jian Dai,

    1. PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China)
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    • These authors contributed equally to this work.

  • Shudong Lin,

    1. PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China)
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    • These authors contributed equally to this work.

  • Dr. Du Cheng,

    1. PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China)
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  • Seyin Zou,

    1. Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510275 (China)
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  • Prof. Xintao Shuai

    Corresponding author
    1. PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China)
    2. Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510275 (China)
    • PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275 (China)
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  • This research was supported by the Natural Science Foundation of China (50830107, 20974129, U1032002) and Guangdong (9351027501000003), the 863 Programs (2009AA03Z310) and Projects for the Creation of Significant New Drugs Programs (2009ZX09501-023) of the Ministry of Science and Technology of China.

Abstract

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On the double: A highly packed interlayer-crosslinked micelle (HP-ICM) with pH and reduction sensitivity was developed for targeted drug release (see picture; DTT=dithiothreitol, red circles=doxorubicin). The HP-ICM suppresses drug leakage in blood circulation while rapidly releasing drug inside lysosomes of cancer cells. Biological studies revealed the potential of the dual-sensitive HP-ICM in cancer treatment.

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