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Gold(I)-Catalyzed Synthesis of Benzoxocines by an 8-endo-dig Cyclization

Authors

  • Dipl.-Chem. Kathrin Wittstein,

    1. Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
    2. Technische Universität Dortmund, Fakultät Chemie, Chemische Biologie, Otto-Hahn-Strasse 6, 44221 Dortmund (Germany)
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  • Dr. Kamal Kumar,

    Corresponding author
    1. Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
    2. Technische Universität Dortmund, Fakultät Chemie, Chemische Biologie, Otto-Hahn-Strasse 6, 44221 Dortmund (Germany)
    • Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
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  • Prof. Dr. Herbert Waldmann

    Corresponding author
    1. Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
    2. Technische Universität Dortmund, Fakultät Chemie, Chemische Biologie, Otto-Hahn-Strasse 6, 44221 Dortmund (Germany)
    • Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
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  • This research leading to these results has received funding from Max-Planck Gesellschaft and the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement n°268309.

Abstract

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A golden dig! Gold-catalyzed direct access to functionalized 2H-1-benzoxocines, eight-membered-ring ethers, is described. This unprecedented synthesis of benzoxocines occurs by an 8-endo-dig cyclization of the 1,7-enyne substrates.

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