A Hemin/G-Quadruplex Acts as an NADH Oxidase and NADH Peroxidase Mimicking DNAzyme

Authors


  • This study wa supported in part by the Israel Science Foundation and the Volkswagen Foundation (Germany).

Abstract

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Enzyme impressionist: A DNAzyme consisting of hemin combined with a G-quadruplex was shown to mimic the activity of NADH oxidase under aerobic conditions and of NADH peroxidase under anaerobic conditions. Along with these new biocatalytic activities, the hemin/G-quadruplex complex is also capable of regenerating the biologically important NAD+ cofactor in both cycles (see picture).

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