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Keywords:

  • alkaloids;
  • asymmetric catalysis;
  • natural products;
  • palladium catalysis;
  • total synthesis
Thumbnail image of graphical abstract

The power of palladium: The total synthesis of the alkaloid hodgkinsine B has been achieved with just six isolated intermediates and only four chromatographic operations. The route involves a palladium-catalyzed enantioselective desymmetrizing N-allylation of meso- chimonanthine to establish the absolute configuration and elaboration of the desymmetrized core by a diastereoselective palladium-catalyzed α-oxindole arylation.