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Keywords:

  • copper;
  • fluorine;
  • homogeneous catalysis;
  • radicals;
  • trifluoromethylation
Thumbnail image of graphical abstract

Activating the inactive: A copper-catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E/Z selectivity (see scheme). The reaction can be applied to a range of substrates bearing numerous functional groups. Furthermore, the reaction is scalable and amenable to a benchtop setup.