We thank the National Institutes of Health (GM46059) for financial support of this project and for a postdoctoral fellowship to A.T.P. (F32GM093532). The Varian 300 MHz and Bruker 400 MHz NMR spectrometers used in this work were supported by grants from the National Science Foundation (ACHE-9808061 and DBI-9729592) and the National Institutes of Health (1S10RR13886-01), respectively.
Copper-Catalyzed Trifluoromethylation of Unactivated Olefins†
Article first published online: 25 AUG 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 39, pages 9120–9123, September 19, 2011
How to Cite
Parsons, A. T. and Buchwald, S. L. (2011), Copper-Catalyzed Trifluoromethylation of Unactivated Olefins. Angew. Chem. Int. Ed., 50: 9120–9123. doi: 10.1002/anie.201104053
- Issue published online: 15 SEP 2011
- Article first published online: 25 AUG 2011
- Manuscript Received: 13 JUN 2011
- National Institutes of Health. Grant Numbers: GM46059, F32GM093532
- National Science Foundation. Grant Numbers: ACHE-9808061, DBI-9729592
- National Institutes of Health. Grant Number: 1S10RR13886-01
- homogeneous catalysis;
Activating the inactive: A copper-catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E/Z selectivity (see scheme). The reaction can be applied to a range of substrates bearing numerous functional groups. Furthermore, the reaction is scalable and amenable to a benchtop setup.