SEARCH

SEARCH BY CITATION

Keywords:

  • IR spectroscopy;
  • kinetics;
  • protein folding;
  • proteins
Thumbnail image of graphical abstract

A new twist: A multi-probe and multi-frequency approach is shown for dissecting the folding dynamics of individual protein structural elements. In response to a temperature jump the 310-helix (blue in the picture) of the miniprotein Trp-cage unfolds before the global unfolding of the protein, whereas the formation of the cage structure depends on the folding of the α-helix (red).