Titania-Supported Iridium Subnanoclusters as an Efficient Heterogeneous Catalyst for Direct Synthesis of Quinolines from Nitroarenes and Aliphatic Alcohols

Authors

  • Lin He,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (P. R. China)
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  • Prof. Dr. Jian-Qiang Wang,

    1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204 (P. R. China)
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  • Ya Gong,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (P. R. China)
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  • Dr. Yong-Mei Liu,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (P. R. China)
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  • Prof. Dr. Yong Cao,

    Corresponding author
    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (P. R. China)
    • Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (P. R. China)
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  • Prof. Dr. He-Yong He,

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (P. R. China)
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  • Prof. Dr. Kang-Nian Fan

    1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433 (P. R. China)
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  • This work was supported by the National Natural Science Foundation of China (20873026 and 21073042), New Century Excellent Talents in the University of China (NCET-09-0305), and the Science and Technology Commission of Shanghai Municipality (08DZ2270500).

Abstract

original image

A versatile heterogeneous catalyst consisting of sub-nanosized iridium clusters deposited on titania (Ir/TiO2-NCs) promotes the direct tandem synthesis of quinoline derivatives from readily available nitroarenes and aliphatic alcohols under mild and additive-free conditions (see scheme). The process tolerates the presence of various reactive functional groups and is highly selective.

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