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Keywords:

  • alkynes;
  • cross-coupling;
  • homogeneous catalysis;
  • iron
Thumbnail image of graphical abstract

The incredible bulk: A highly Cmath image-center-selective alkynylation of nonactivated alkyl halides with the corresponding Grignard reagents is achieved by using the iron-phosphine complex 1. Primary and secondary alkyl iodides, bromides, and chlorides take part in the reaction to give the substituted alkynes in good to excellent yields. Sequential cyclization/cross-coupling reactions are also demonstrated.