Indium Tribromide Catalyzed Cross-Claisen Condensation between Carboxylic Acids and Ketene Silyl Acetals Using Alkoxyhydrosilanes


  • This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (No. 22106527, “Organic Synthesis Based on Reaction Integration. Development of New Methods and Creation of New Substances”) and Scientific Research (No. 21350074) from the Ministry of Education, Culture, Sports, Science and Technology (Japan).


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Acylations achieved: The title reaction between carboxylic acids and ketene silyl acetals has been accomplished (see scheme). The additive, (MeO)3SiH, is believed to play an important role in the promotion of the condensation reaction. This reaction system was compatible with a diverse range of functional groups, including alkenes, alkynes, chlorides, alcohols, esters, and nitro groups.