This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (No. 22106527, “Organic Synthesis Based on Reaction Integration. Development of New Methods and Creation of New Substances”) and Scientific Research (No. 21350074) from the Ministry of Education, Culture, Sports, Science and Technology (Japan).
Indium Tribromide Catalyzed Cross-Claisen Condensation between Carboxylic Acids and Ketene Silyl Acetals Using Alkoxyhydrosilanes†
Article first published online: 26 JUL 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 37, pages 8623–8625, September 5, 2011
How to Cite
Nishimoto, Y., Okita, A., Yasuda, M. and Baba, A. (2011), Indium Tribromide Catalyzed Cross-Claisen Condensation between Carboxylic Acids and Ketene Silyl Acetals Using Alkoxyhydrosilanes. Angew. Chem. Int. Ed., 50: 8623–8625. doi: 10.1002/anie.201104140
- Issue published online: 1 SEP 2011
- Article first published online: 26 JUL 2011
- Manuscript Received: 16 JUN 2011
- Ministry of Education, Culture, Sports, Science and Technology. Grant Numbers: 22106527, 21350074
- carboxylic acids;
- Claisen condensation;
- ketene silyl acetals;
Acylations achieved: The title reaction between carboxylic acids and ketene silyl acetals has been accomplished (see scheme). The additive, (MeO)3SiH, is believed to play an important role in the promotion of the condensation reaction. This reaction system was compatible with a diverse range of functional groups, including alkenes, alkynes, chlorides, alcohols, esters, and nitro groups.