Ionic-Surfactant-Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols

Authors

  • Hyunjin Kim,

    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Yoon Kyung Choi,

    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Jusuk Lee,

    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Eungyeong Lee,

    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Jaiwook Park,

    Corresponding author
    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
    • Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • Prof. Mahn-Joo Kim

    Corresponding author
    1. Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
    • Department of Chemistry, Pohang University of Science and Technology (POSTECH), San-31 Hyojadong, Pohang 790-784 (Republic of Korea)
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  • This work was supported by the National Research Foundation of Korea (KRF-2007-511-C00031 and 2009-0074357).

Abstract

original image

With a coat for activity: A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). Important features of this enzyme include: the fastest DKR of 1-phenylethanol, the highly enantioselective DKR of a wide range of secondary alcohols (RCH(OH)Ar), and the switching of lipase enantioselectivity in DKR depending on the shape of the aliphatic chain (R).

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