Communication

Inhibition of Beta-Amyloid Peptide Aggregation by Multifunctional Carbazole-Based Fluorophores†

  1. Wanggui Yang1,‡,
  2. Yi Wong1,‡,
  3. Dr. Olivia T. W. Ng2,‡,
  4. Dr. Li-Ping Bai3,
  5. Prof. Daniel W. J. Kwong1,
  6. Prof. Ya Ke4,
  7. Prof. Zhi-Hong Jiang3,
  8. Prof. Hung-Wing Li1,*,
  9. Prof. Ken K. L. Yung2,*,
  10. Prof. Man Shing Wong1,*

Article first published online: 15 NOV 2011

DOI: 10.1002/anie.201104150

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 8, pages 1804–1810, February 20, 2012

Additional Information

How to Cite

Yang, W., Wong, Y., Ng, O. T. W., Bai, L.-P., Kwong, D. W. J., Ke, Y., Jiang, Z.-H., Li, H.-W., Yung, K. K. L. and Wong, M. S. (2012), Inhibition of Beta-Amyloid Peptide Aggregation by Multifunctional Carbazole-Based Fluorophores. Angew. Chem. Int. Ed., 51: 1804–1810. doi: 10.1002/anie.201104150

Author Information

  1. 1

    Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong (P. R. China)

  2. 2

    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong (P. R. China)

  3. 3

    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong (P. R. China)

  4. 4

    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong (P. R. China)

  1. ‡

    These authors contributed equally to this work.

*Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong (P. R. China)

  1. †

    This work was financially supported by the Research Grant Council of the Hong Kong Special Administrative Region, P. R. China (HKBU201208 for H.W.L.; HKBU262107 and HKBU262210 for K.K.L.Y.; HKBU202408 for M.S.W.; and, HKBU2607/09M for Z.H.J.). K.K.L.Y. also thanks the Hong Kong Baptist University Research Committee (RC/AOE/08-09/02). We thank Mr. Chun-Tak Lau at Chemistry Department, Hong Kong University of Science and Technology for assistance with CD measurements. The FEI-Technai G2 TEM used in this work was supported by the Centre for Surface Analysis and Research (CSAR) with funding from the Special Equipment Grant from the University Grant Committee of the Hong Kong Special Administrative Region, China (SEG_HKBU06).

Publication History

  1. Issue published online: 14 FEB 2012
  2. Article first published online: 15 NOV 2011
  3. Manuscript Revised: 31 AUG 2011
  4. Manuscript Received: 16 JUN 2011

Funded by

  • Hong Kong Special Administrative Region, P. R. China. Grant Numbers: HKBU201208, HKBU262107, HKBU262210, HKBU202408, HKBU2607/09M
  • Hong Kong Baptist University Research Committee. Grant Number: RC/AOE/08-09/02
  • Special Equipment Grant from the University Grant Committee of the Hong Kong Special Administrative Region, China. Grant Number: (SEG_HKBU06)

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (6029K)

Keywords:

  • Alzheimer’s disease;
  • beta-amyloid peptide;
  • fluorophores;
  • inhibitors
Thumbnail image of graphical abstract

Stopping aggregation: Carbazole-based cyanine fluorophores bind selectively to the Aβ(1–40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ(1–40) fibrillogenesis (see scheme) and can pass through the blood-brain barrier making it a potential therapeutic agent for Alzheimer's disease.

View Full Article with Supporting Information (HTML) Get PDF (6029K)