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Back Cover: Artificial Molecular Clamp: A Novel Device for Synthetic Polymerases (Angew. Chem. Int. Ed. 33/2011)

Authors

  • Dr. Yoshinori Takashima,

    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
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  • Dr. Motofumi Osaki,

    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
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  • Prof. Dr. Yoshihiro Ishimaru,

    1. Department of Functional Materials Science, School of Engineering, Saitama University (Japan)
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  • Dr. Hiroyasu Yamaguchi,

    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
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  • Prof. Dr. Akira Harada

    Corresponding author
    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
    2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Sanban-cho Building, 4F, 5 Sanban-cho, Chiyoda-ku, Tokyo 102-0075 (Japan)
    • Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
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Abstract

original image

A synthetic polymerase including a cyclodextrin dimer is used to produce high-molecular-weight polymers. In their Communication on page 7524 ff., A. Harada and co-workers report that one CD moiety (green) of the dimer acts as the active site of the polymerization, whereas the other moiety (purple) serves as an artifical molecular clamp that propagates the polymerization by holding the polymer chain (blue). This system is reminiscent of the DNA polymerase shown in the background of the picture.

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