These authors contributed equally to this work.
Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters†
Article first published online: 25 AUG 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 39, pages 9124–9127, September 19, 2011
How to Cite
Cao, Y., Jiang, X., Liu, L., Shen, F., Zhang, F. and Wang, R. (2011), Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters. Angew. Chem. Int. Ed., 50: 9124–9127. doi: 10.1002/anie.201104216
We are grateful for the grants from the National Natural Science Foundation of China (nos. 20932003 and 90813012), the Key National S&T Program “Major New Drug Development” of the Ministry of Science and Technology of China (2009ZX09503-017).
- Issue published online: 15 SEP 2011
- Article first published online: 25 AUG 2011
- Manuscript Received: 19 JUN 2011
- National Natural Science Foundation of China. Grant Numbers: 20932003, 90813012
- Ministry of Science and Technology of China. Grant Number: 2009ZX09503-017
- asymmetric synthesis;
- Michael addition;
- synthetic methods
A-spiro-ing: The title reaction of α-isothiocyanato imides and methyleneindolinones has been realized for the first time using 1 as the catalyst. This newly developed synthetic method provides a simple, efficient, and environmentally friendly way to access, in an enantioselective manner, densely functionalized spirooxindoles having three contiguous stereogenic centers.