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Keywords:

  • asymmetric synthesis;
  • heterocycles;
  • Michael addition;
  • organocatalysis;
  • synthetic methods
Thumbnail image of graphical abstract

A-spiro-ing: The title reaction of α-isothiocyanato imides and methyleneindolinones has been realized for the first time using 1 as the catalyst. This newly developed synthetic method provides a simple, efficient, and environmentally friendly way to access, in an enantioselective manner, densely functionalized spirooxindoles having three contiguous stereogenic centers.