This work was funded by the State of Mecklenburg-Western Pomerania, the BMBF, and the DFG (Leibniz Prize). We thank Dr. W. Baumann, Dr. C. Fischer, S. Buchholz, S. Schareina, A. Kammer, A. Koch, B. Wendt, S. Rossmeisl, and K. Mevius (all at the LIKAT) for their excellent technical and analytical support.
Selective Catalytic Monoreduction of Phthalimides and Imidazolidine-2,4-diones†
Article first published online: 24 AUG 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 39, pages 9180–9184, September 19, 2011
How to Cite
Das, S., Addis, D., Knöpke, L. R., Bentrup, U., Junge, K., Brückner, A. and Beller, M. (2011), Selective Catalytic Monoreduction of Phthalimides and Imidazolidine-2,4-diones. Angew. Chem. Int. Ed., 50: 9180–9184. doi: 10.1002/anie.201104226
- Issue published online: 15 SEP 2011
- Article first published online: 24 AUG 2011
- Manuscript Received: 19 JUN 2011
- State of Mecklenburg-Western Pomerania
- homogeneous catalysis;
Fluoride's new role: Selective and efficient monoreductions of imides can be achieved with polymethylhydrosiloxane (PMHS) and tetra-n-butylammonium fluoride (TBAF) as catalyst (see scheme). The system is characterized by good chemoselectivity, operational simplicity, and functional-group tolerance; a concise mechanistic proposal was possible from in situ spectroscopic investigations.