Get access

Selective Catalytic Monoreduction of Phthalimides and Imidazolidine-2,4-diones


  • This work was funded by the State of Mecklenburg-Western Pomerania, the BMBF, and the DFG (Leibniz Prize). We thank Dr. W. Baumann, Dr. C. Fischer, S. Buchholz, S. Schareina, A. Kammer, A. Koch, B. Wendt, S. Rossmeisl, and K. Mevius (all at the LIKAT) for their excellent technical and analytical support.


original image

Fluoride's new role: Selective and efficient monoreductions of imides can be achieved with polymethylhydrosiloxane (PMHS) and tetra-n-butylammonium fluoride (TBAF) as catalyst (see scheme). The system is characterized by good chemoselectivity, operational simplicity, and functional-group tolerance; a concise mechanistic proposal was possible from in situ spectroscopic investigations.

Get access to the full text of this article