Convergent Total Synthesis of (+)-Ophiobolin A


  • This work was financially supported in part by a Waseda University Grant for Special Research Projects, a Grant-in-Aid for Scientific Research on Innovative Areas (No. 21106009), Young Scientists (No. 19890231), and the Global COE program “Center for Practical Chemical Wisdom” by MEXT.


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At long last: The enantioselective total synthesis of the title compound, which was isolated in 1958, proceeds by a convergent approach. The assembly of the C, D-ring fragment and the A-ring fragment of the core structure is achieved by employing a Reformatsky-type reaction. The eight-membered carbocyclic B ring is efficiently constructed by a challenging ring-closing metathesis (see scheme).