Get access
Advertisement

Convergent Total Synthesis of (+)-Ophiobolin A

Authors


  • This work was financially supported in part by a Waseda University Grant for Special Research Projects, a Grant-in-Aid for Scientific Research on Innovative Areas (No. 21106009), Young Scientists (No. 19890231), and the Global COE program “Center for Practical Chemical Wisdom” by MEXT.

Abstract

original image

At long last: The enantioselective total synthesis of the title compound, which was isolated in 1958, proceeds by a convergent approach. The assembly of the C, D-ring fragment and the A-ring fragment of the core structure is achieved by employing a Reformatsky-type reaction. The eight-membered carbocyclic B ring is efficiently constructed by a challenging ring-closing metathesis (see scheme).

Get access to the full text of this article

Ancillary