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Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration†

  1. Vikash P. Chauhan1,3,‡,
  2. Dr. Zoran Popović2,‡,
  3. Dr. Ou Chen2,
  4. Jian Cui2,
  5. Prof. Dr. Dai Fukumura1,
  6. Prof. Dr. Moungi G. Bawendi2,*,
  7. Prof. Dr. Rakesh K. Jain1,*

Article first published online: 6 OCT 2011

DOI: 10.1002/anie.201104449

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 48, pages 11417–11420, November 25, 2011

Additional Information

How to Cite

Chauhan, V. P., Popović, Z., Chen, O., Cui, J., Fukumura, D., Bawendi, M. G. and Jain, R. K. (2011), Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration. Angew. Chem. Int. Ed., 50: 11417–11420. doi: 10.1002/anie.201104449

Author Information

  1. 1

    Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St., Boston, MA 02114 (USA)

  2. 2

    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)

  3. 3

    Harvard School of Engineering and Applied Sciences, Harvard University (USA)

  1. ‡

    These authors contributed equally to this work.

*Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)

  1. †

    We thank Debby Pheasant (BIF Facility, MIT), Julia Kahn (MGH), and Sylvie Roberge (MGH) for technical assistance. This research was supported by the U.S. National Cancer Institute grants R01-CA126642 (R.K.J. and M.G.B.), R01-CA085140, R01-CA115767 (R.K.J.), P01-CA080124 (R.K.J. and D.F.), R01-CA096915 (D.F.); by the U.S. Department of Defense Breast Cancer Research Program Innovator Award W81XWH-10-1-0016 (R.K.J.); by the MIT-Harvard NIH Center for Cancer Nanotechnology Excellence 1U54-CA119349 (M.G.B.); by the MIT DCIF CHE-980806, DBI-9729592; by the ISN W911NF-07-D-0004 (M.G.B); by the NSF-MRSEC program (DMR-0117795) via the use of its shared user facilities.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 18 NOV 2011
  2. Article first published online: 6 OCT 2011
  3. Manuscript Revised: 16 AUG 2011
  4. Manuscript Received: 27 JUN 2011

Funded by

  • U.S. National Cancer Institute. Grant Numbers: R01-CA126642, R01-CA085140, R01-CA115767, P01-CA080124, R01-CA096915
  • U.S. Department of Defense Breast Cancer Research Program Innovator Award. Grant Number: W81XWH-10-1-0016
  • MIT-Harvard NIH Center for Cancer Nanotechnology Excellence. Grant Number: 1U54-CA119349
  • MIT DCIF. Grant Numbers: CHE-980806, DBI-9729592
  • ISN. Grant Number: W911NF-07-D-0004
  • NSF-MRSEC. Grant Number: DMR-0117795

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