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Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

Authors

  • Vikash P. Chauhan,

    1. Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St., Boston, MA 02114 (USA)
    2. Harvard School of Engineering and Applied Sciences, Harvard University (USA)
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    • These authors contributed equally to this work.

  • Dr. Zoran Popović,

    1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
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    • These authors contributed equally to this work.

  • Dr. Ou Chen,

    1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
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  • Jian Cui,

    1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
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  • Prof. Dr. Dai Fukumura,

    1. Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St., Boston, MA 02114 (USA)
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  • Prof. Dr. Moungi G. Bawendi,

    Corresponding author
    1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
    • Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139 (USA)
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  • Prof. Dr. Rakesh K. Jain

    Corresponding author
    1. Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St., Boston, MA 02114 (USA)
    • Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom St., Boston, MA 02114 (USA)
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  • We thank Debby Pheasant (BIF Facility, MIT), Julia Kahn (MGH), and Sylvie Roberge (MGH) for technical assistance. This research was supported by the U.S. National Cancer Institute grants R01-CA126642 (R.K.J. and M.G.B.), R01-CA085140, R01-CA115767 (R.K.J.), P01-CA080124 (R.K.J. and D.F.), R01-CA096915 (D.F.); by the U.S. Department of Defense Breast Cancer Research Program Innovator Award W81XWH-10-1-0016 (R.K.J.); by the MIT-Harvard NIH Center for Cancer Nanotechnology Excellence 1U54-CA119349 (M.G.B.); by the MIT DCIF CHE-980806, DBI-9729592; by the ISN W911NF-07-D-0004 (M.G.B); by the NSF-MRSEC program (DMR-0117795) via the use of its shared user facilities.

Abstract

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Shape dependent: Fluorescent quantum-dot-based nanospheres and nanorods with identical hydrodynamic size and surface properties but different aspect ratios were developed for real-time in vivo tumor imaging. The nanorods exhibited superior transport and distribution into mammary tumors in vivo versus nanospheres of similar plasma half-life.

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