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Short, Enantioselective Total Syntheses of (−)-8-Demethoxyrunanine and (−)-Cepharatines A, C, and D


  • We thank Dr. Michael Day and Mr. Larry Henling for X-ray crystallographic structural determination, as well as Prof. Brian Stoltz, Dr. Scott Virgil, and the Caltech Center for Catalysis and Chemical Synthesis for access to analytical equipment. Fellowship support was provided by the Gates Millennium Scholars Program (R.N.), the NIH (R.N., 1F31GM098025A) and the Amgen Scholars Program (K.V.C.). HRMS and X-ray crystallographic data were obtained on instruments purchased through awards to the California Institute of Technology by the NSF CRIF program (CHE-0639094, CHE-0541745). Financial support from the California Institute of Technology and the NSF (CAREER-1057143) is gratefully acknowledged.


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All together! A unified synthetic strategy has resulted in the first enantioselective total syntheses of the natural products 8-demethoxyrunanine and cepharatines A, C, and D.