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Keywords:

  • antitumor agents;
  • atropisomerism;
  • Friedel–Crafts reaction;
  • natural products;
  • total synthesis
Thumbnail image of graphical abstract

Turn up the heat: The synthesis of the title compound was achieved and a route to epoxide-containing diazobenzofluorenes, which could potentially serve as monomers to the dimeric lomaiviticins, was established. Key steps to construct the FL-120B′ core structure include Sharpless asymmetric epoxidation, Stille coupling, and intramolecular Friedel–Crafts acylation of atropisomeric carboxylic acids at elevated temperatures.