X-Ray Computed Tomography Imaging of Breast Cancer by using Targeted Peptide-Labeled Bismuth Sulfide Nanoparticles

Authors

  • Dr. Joseph M. Kinsella,

    1. Department of Chemistry & Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
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  • Rebecca E. Jimenez,

    1. Department of Biomedical Sciences, University of California (USA)
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  • Priya P. Karmali,

    1. Center for Nanomedicine, Sanford Burnham Medical Research Institute at University of California, Santa Barbara, 1105 Life Sciences Technology Bldg, Santa Barbara, CA 93106 (USA)
    2. Cancer Center Sanford Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037 (USA)
    3. Present address: Nitto Denko Technical Corporation, 501 Via Del Monte, Oceanside, CA 92058 (USA)
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  • Anthony M. Rush,

    1. Department of Chemistry & Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
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  • V. Ramana Kotamraju,

    1. Center for Nanomedicine, Sanford Burnham Medical Research Institute at University of California, Santa Barbara, 1105 Life Sciences Technology Bldg, Santa Barbara, CA 93106 (USA)
    2. Cancer Center Sanford Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Prof. Nathan C. Gianneschi,

    1. Department of Chemistry & Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
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  • Prof. Erkki Ruoslahti,

    1. Center for Nanomedicine, Sanford Burnham Medical Research Institute at University of California, Santa Barbara, 1105 Life Sciences Technology Bldg, Santa Barbara, CA 93106 (USA)
    2. Cancer Center Sanford Burnham Medical Research Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Dr. Dwayne Stupack,

    1. Moores Cancer Center, University of California (USA)
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  • Prof. Michael J. Sailor

    Corresponding author
    1. Department of Chemistry & Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
    2. Materials Science and Engineering, University of California (USA)
    3. Department of Bioengineering, University of California (USA)
    • Department of Chemistry & Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (USA)
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  • This work was supported by the National Cancer Institute of the National Institutes of Health through grant numbers U5A CA 119335 (UCsD CCNE) and 5-R01-CA124427 (Bioengineering Research Partnership). J.M.K. acknowledges support from the American Cancer Society in the form of a postdoctoral fellowship. We acknowledge use of the UCSD Cryo-Electron Microscopy Facility, which is supported in part by NIH grant 1S10 RR020016, a gift from the Agouron Institute, and UCSD funds provided to Prof. Timothy S. Baker.

Abstract

original image

Enhanced visualization of breast cancer in X-ray computed tomography was achieved by using Bi2S3 nanoparticles of 10 nm diameter modified to display a tumor targeting peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260 % over non-labeled nanoparticles.

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