SEARCH

SEARCH BY CITATION

Keywords:

  • antitumor agents;
  • drug delivery;
  • nanoparticles;
  • oxaliplatin;
  • polysilsesquioxanes
Thumbnail image of graphical abstract

Trigger happy: Polysilsesquioxane (PSQ) nanoparticles that contain a PtIV-based active agent (1; see picture) can be used for the triggered delivery of chemotherapeutics. The cytotoxicity of 1 was superior to that of oxaliplatin against four cancer cell lines in vitro, and targeting further enhanced the cytotoxicity. PEGylated and anisamide-targeted 1 showed drastically superior efficacy to oxaliplatin in inhibiting tumor growth.