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Cover Picture: Total Synthesis of (+)-Omphadiol (Angew. Chem. Int. Ed. 33/2011)

Authors

  • Gang Liu,

    1. Department of Chemistry, Texas A&M University, P. O. Box 30012, College Station, TX 77842 (USA)
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  • Prof. Dr. Daniel Romo

    Corresponding author
    1. Department of Chemistry, Texas A&M University, P. O. Box 30012, College Station, TX 77842 (USA)
    • Department of Chemistry, Texas A&M University, P. O. Box 30012, College Station, TX 77842 (USA)
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Abstract

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A high ratio of C[BOND]C bond-forming steps and a high degree of stereocontrol characterizes the first total synthesis of (+)-omphadiol. In their Communication on page 7537 ff., D. Romo and G. Lui report a facile conversion of (R)-carvone, from the spearmint plant, into omphadiol, from the jack-o'-lantern mushroom, via a versatile bicyclic β-lactone. Several one-pot or sequential processes and the absence of protecting groups contribute to the brevity of the synthesis.

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