Communication

Simultaneous Photographing of Oxygen and pH In Vivo Using Sensor Films†

  1. Dr. Robert J. Meier1,‡,
  2. Dr. Stephan Schreml2,‡,
  3. Dr. Xu-dong Wang1,
  4. Prof. Michael Landthaler2,
  5. Dr. Philipp Babilas2,
  6. Prof. Otto S. Wolfbeis1,*

Article first published online: 27 SEP 2011

DOI: 10.1002/anie.201104530

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 46, pages 10893–10896, November 11, 2011

Additional Information

How to Cite

Meier, R. J., Schreml, S., Wang, X.-d., Landthaler, M., Babilas, P. and Wolfbeis, O. S. (2011), Simultaneous Photographing of Oxygen and pH In Vivo Using Sensor Films. Angew. Chem. Int. Ed., 50: 10893–10896. doi: 10.1002/anie.201104530

Author Information

  1. 1

    Institut für Analytische Chemie, Chemo- und Biosensorik, Universität Regensburg, 93040 Regensburg (Germany) http://www.wolfbeis.de

  2. 2

    Klinik und Poliklinik für Dermatologie, Universitätsklinikum Regensburg (Germany)

  1. ‡

    These authors contributed equally to this work.

*Institut für Analytische Chemie, Chemo- und Biosensorik, Universität Regensburg, 93040 Regensburg (Germany) http://www.wolfbeis.de

  1. †

    The authors are grateful to the Deutsche Forschungsgemeinschaft for grants WO 669/9-1 and BA 3410/4-1, and the Novartis Foundation Novartis Graduate Scholarship (to S.S.). X.W. thanks the German Academic Exchange Service (DAAD) for a grant. The authors thank Josef Schroeder and Heiko Siegmund (Institute of Pathology) for electron microscopic images, Tim Maisch, Johannes Regensburger, and Francesco Santarelli (Department of Dermatology) for keratinocyte cultures and singlet oxygen detection, Karla Lehle and Christina Leykauf (Department of Cardiothoracic Surgery) for cell cultures and cytotoxicity tests, Judith Stolwijk (Institute of Analytical Chemistry, Chemo- and Biosensors) for confocal microscopic imaging, and Timo Lauber and Dietmar Schreml for their help with video processing.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 9 NOV 2011
  2. Article first published online: 27 SEP 2011
  3. Manuscript Received: 30 JUN 2011

Funded by

  • Deutsche Forschungsgemeinschaft. Grant Numbers: WO 669/9-1, BA 3410/4-1
  • Novartis Foundation
  • DAAD

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (933K)

Keywords:

  • diagnostics;
  • dual sensing;
  • fluorescence;
  • imaging;
  • wound healing
Thumbnail image of graphical abstract

Two kinds of imaging: A fluorescent sensor membrane is presented that responds to pH and to pO2 at different emission wavelengths. The fluorescence intensities can be imaged with a digital camera using the red-green-blue (RGB) data storage option.

View Full Article with Supporting Information (HTML) Get PDF (933K)