We thank Dr. Marc LaFrance for his assistance in ligand synthesis.
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Communication
Catalytic Asymmetric Intramolecular Hydroacylation with Rhodium/Phosphoramidite–Alkene Ligand Complexes†
Article first published online: 16 SEP 2011
DOI: 10.1002/anie.201104595
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 50, Issue 45, pages 10670–10674, November 4, 2011
Additional Information
How to Cite
Hoffman, T. J. and Carreira, E. M. (2011), Catalytic Asymmetric Intramolecular Hydroacylation with Rhodium/Phosphoramidite–Alkene Ligand Complexes. Angewandte Chemie International Edition, 50: 10670–10674. doi: 10.1002/anie.201104595
- †
Publication History
- Issue published online: 28 OCT 2011
- Article first published online: 16 SEP 2011
- Manuscript Received: 4 JUL 2011
Keywords:
- asymmetric catalysis;
- cyclopentanone;
- hydroacylation;
- P ligands;
- rhodium
Graphical Abstract
Give me a P: An asymmetric intramolecular Rh-catalyzed hydroacylation reaction of pent-4-enals for the preparation of functionalized cyclopentanones in good yield and high enantioselectivity is described (see scheme, DCE=dichloroethane). This process uses rhodium complexes featuring novel modular phosphoramidite–alkene ligands and achiral phosphine coligands.