Protein Transduction Domain Mimics: The Role of Aromatic Functionality


  • Generous support was primarily provided by the NSF (CHE-0910963). Dr. Semra Colak is acknowledged for her contribution in octyl monomer synthesis.


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For better or worse: Protein transduction domain mimics built from synthetic polymers demonstrate that aromatic side chains provide better transduction than aliphatic groups at the same relative hydrophobicity. Similarly, a less hydrophobic aromatic side chain is more active than the corresponding aliphatic one containing the same number of carbon atoms (see picture).