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Keywords:

  • cyclization;
  • nucleophilic addition;
  • organocatalysis;
  • selenium;
  • spiro compounds
Thumbnail image of graphical abstract

Spiroring in control: A novel organocatalytic Michael addition/cyclization sequence based on the bis(electrophilic) properties of vinyl selenones has been successfully employed for the synthesis of densely functionalized spirocyclic compounds (see scheme). By using a simple one-pot procedure and mild reaction conditions, spirocyclic compounds were synthesized in high yields and with high levels of enantioselectivity (90–98 % ee).