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DNA-Catalyzed Reductive Amination


  • This research was supported by grants to S.K.S. by the National Institutes of Health (grant number GM065966), the Defense Threat Reduction Agency (grant number BRBAA08-L-2-0001), and the National Science Foundation (grant number 0842534). We are grateful to the anonymous reviewers and Amit Sachdeva for their insightful comments and experimental suggestions.


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A new reaction for DNA: DNA is shown to catalyze Ni2+-dependent reductive amination involving the N2-amine of a guanosine nucleobase (see picture). This finding expands the repertoire of nucleic acid catalysis to include reductive amination, an important natural biosynthetic reaction that has practical synthetic utility.