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Keywords:

  • membrane proteins;
  • NMR spectroscopy;
  • structural biology;
  • structure elucidation
Thumbnail image of graphical abstract

Membrane proteins in their native cellular membranes are accessible by dynamic nuclear polarization magic angle spinning solid-state NMR spectroscopy without the need of purification and reconstitution (see picture). Dynamic nuclear polarization is essential to achieve the required gain in sensitivity to observe the membrane protein of interest.