G.S.K., C.U.M., and R.A.K. thank the Council of Scientific and Industrial Research (CSIR), India, for their fellowship.
Copper-Catalyzed Oxidative CO Coupling by Direct CH Bond Activation of Formamides: Synthesis of Enol Carbamates and 2-Carbonyl-Substituted Phenol Carbamates†
Article first published online: 12 OCT 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 49, pages 11748–11751, December 2, 2011
How to Cite
Kumar, G. S., Maheswari, C. U., Kumar, R. A., Kantam, M. L. and Reddy, K. R. (2011), Copper-Catalyzed Oxidative CO Coupling by Direct CH Bond Activation of Formamides: Synthesis of Enol Carbamates and 2-Carbonyl-Substituted Phenol Carbamates. Angew. Chem. Int. Ed., 50: 11748–11751. doi: 10.1002/anie.201105020
- Issue published online: 28 NOV 2011
- Article first published online: 12 OCT 2011
- Manuscript Received: 18 JUL 2011
- homogeneous catalysis;
- oxidative coupling;
- synthetic methods
Formamide CH bond activation has been achieved under oxidative conditions, using a copper catalyst and tert-butyl hydroperoxide (TBHP) as the external oxidant (see scheme). This oxidative coupling of a range of dialkyl formamides provides an easy, phosgene-free route for the selective synthesis of Z-enol carbamates and 2-carbonyl-substituted phenol carbamates in high yields.