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Keywords:

  • carbamates;
  • copper;
  • homogeneous catalysis;
  • oxidative coupling;
  • synthetic methods
Thumbnail image of graphical abstract

Formamide C[BOND]H bond activation has been achieved under oxidative conditions, using a copper catalyst and tert-butyl hydroperoxide (TBHP) as the external oxidant (see scheme). This oxidative coupling of a range of dialkyl formamides provides an easy, phosgene-free route for the selective synthesis of Z-enol carbamates and 2-carbonyl-substituted phenol carbamates in high yields.