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Keywords:

  • coenzyme B12;
  • enzyme catalysis;
  • magnetic field effects;
  • protein dynamics;
  • radical pair reactions
Thumbnail image of graphical abstract

“Cohort-ry” in motion: The chemistry following Co[BOND]C bond homolysis in coenzyme B12-dependent ethanolamine ammonia lyase is known to favor dissociation, but what of the protein contribution? Experiments reveal the radical pair reaction dynamics to be coupled to the ps–ns protein dynamics in B12 photolysis. This raises the possibility of a subtle, dynamic contribution to homolysis, which acts in cohort with electrostatics and H-abstraction from the substrate.