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Keywords:

  • conformation analysis;
  • L-iduronic acid;
  • polymorphism;
  • structure elucidation;
  • X-ray diffraction
Thumbnail image of graphical abstract

Crystal clear: After two decades of controversy the elusive skew-boat conformation of L-iduronic acid (see picture) was finally ascertained at atomic resolution in a synthetic, substituted disaccharide. This highly flexible compound crystallizes in two dimorphs. This rare case of dimorphism in oligosaccharides is all the more remarkable in that the 2SO conformation crystallizes in both forms.