Dendrimer-Mediated Multivalent Binding for the Enhanced Capture of Tumor Cells


  • This work was supported by the National Science Foundation (NSF) under grant no. CBET-0931472. This investigation was conducted in a facility constructed with support from the NCRR, NIH (grant C06RR15482). This research was also partially supported by the NCI, NIH (U54 CA151880), and the Chicago Biomedical Consortium.


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A naturally occurring multivalent binding effect is manipulated by engineering cell capture surfaces using dendrimers. The enhanced binding through the multivalent effect significantly improves detection of tumor cells. This improvement can be potentially translated into clinically significant detection of circulating tumor cells from the blood of cancer patients.