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Rhodium-Catalyzed Intermolecular [2+2+2] Cross-Trimerization of Aryl Ethynyl Ethers and Carbonyl Compounds To Produce Dienyl Esters


  • This work was supported partly by a Grant-in-Aid for Scientific Research (No. 20675002) from MEXT (Japan). We are grateful to Takasago International Corporation for the gift of H8-binap and segphos, and Umicore for generous support in supplying a rhodium complex.


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Positive thinking: A cationic rhodium(I)/H8-binap complex catalyzes the chemo-, regio-, and stereoselective completely intermolecular [2+2+2] cross-trimerization of two aryl ethynyl ethers with both electron-deficient and electron-rich carbonyl compounds (see scheme; cod=1,5-cyclooctadiene). This reaction proceeded at room temperature to give aryloxy-substituted dienyl esters in good yields.

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