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Keywords:

  • dipicolylamines;
  • drug delivery;
  • hyaluronic acid;
  • nanoparticles;
  • siRNA
Thumbnail image of graphical abstract

Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a ZnII-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).