These authors contributed equally to this work.
Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate†
Article first published online: 23 NOV 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 2, pages 445–449, January 9, 2012
How to Cite
Liu, G., Choi, K. Y., Bhirde, A., Swierczewska, M., Yin, J., Lee, S. W., Park, J. H., Hong, J. I., Xie, J., Niu, G., Kiesewetter, D. O., Lee, S. and Chen, X. (2012), Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate . Angew. Chem. Int. Ed., 51: 445–449. doi: 10.1002/anie.201105565
This work was supported by the Intramural Research Program of the NIBIB, NIH and partially supported by an NIH Pathway to Independence (K99/R00) Award, the National Natural Science Foundation of China (NSFC, grant nos. 81101101 and 2011JQ0032), the International Cooperative Program of the NSFC (grant no. 81028009), and NRF grant 2009-0080734 from the MEST (Korea).
- Issue published online: 4 JAN 2012
- Article first published online: 23 NOV 2011
- Manuscript Revised: 10 OCT 2011
- Manuscript Received: 6 AUG 2011
- NIBIB, NIH
- National Natural Science Foundation of China . Grant Numbers: 81101101, 2011JQ0032, 81028009, 2009-0080734
- drug delivery;
- hyaluronic acid;
Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a ZnII-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).