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Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate

Authors

  • Dr. Gang Liu,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
    2. Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College (China)
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    • These authors contributed equally to this work.

  • Dr. Ki Young Choi,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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    • These authors contributed equally to this work.

  • Dr. Ashwinkumar Bhirde,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Magdalena Swierczewska,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Dr. Juan Yin,

    1. National Cancer Institute (NCI), National Institutes of Health (USA)
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  • Sang Wook Lee,

    1. Department of Chemistry, Seoul National University (Korea)
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  • Prof. Jae Hyung Park,

    1. Department of Polymer Science and Engineering, Sungkyunkwan University (Korea)
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  • Prof. Jong In Hong,

    1. Department of Chemistry, Seoul National University (Korea)
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  • Prof. Jin Xie,

    1. Department of Chemistry and Bio-Imaging Research Center, University of Georgia (USA)
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  • Dr. Gang Niu,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Dr. Dale O. Kiesewetter,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Dr. Seulki Lee,

    Corresponding author
    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
    • Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • Dr. Xiaoyuan Chen

    Corresponding author
    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
    • Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (USA)
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  • This work was supported by the Intramural Research Program of the NIBIB, NIH and partially supported by an NIH Pathway to Independence (K99/R00) Award, the National Natural Science Foundation of China (NSFC, grant nos. 81101101 and 2011JQ0032), the International Cooperative Program of the NSFC (grant no. 81028009), and NRF grant 2009-0080734 from the MEST (Korea).

Abstract

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Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a ZnII-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).

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