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Gold Nanoclusters and Graphene Nanocomposites for Drug Delivery and Imaging of Cancer Cells

Authors

  • Chensu Wang,

    1. State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, No. 2 Sipailou, Nanjing 210096 (China)
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    • These authors contributed equally to this work.

  • Jingyuan Li,

    1. State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, No. 2 Sipailou, Nanjing 210096 (China)
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    • These authors contributed equally to this work.

  • Prof. Christian Amatore,

    1. Ecole Normale Supérieure, UMR CNRS-ENS-UPMC 8640 and LIA CNRS XiamENS NanoBioChem Département de Chimie (France)
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  • Prof. Yu Chen,

    1. Key Laboratory for Advanced Materials, Institute of Applied Chemistry, East China University of Science and Technology, Shanghai (P.R. China)
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  • Dr. Hui Jiang,

    1. State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, No. 2 Sipailou, Nanjing 210096 (China)
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  • Prof. Xue-Mei Wang

    Corresponding author
    1. State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, No. 2 Sipailou, Nanjing 210096 (China)
    • State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, No. 2 Sipailou, Nanjing 210096 (China)
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  • In China, this work was supported by the National Key Basic Research Program (2010CB732404), the National Natural Science Foundation of China (21175020), the Doctoral Fund of the Ministry of Education of China (RFDP20090092110028), the Natural Science Foundation of Jiangsu Province (BK2008149), the Fundamental Research Funds for the Central Universities, the Shanghai Eastern Scholarship, the Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), and the Ministry of Education. In France, it was supported by the CNRS, the ENS, and the UPMC (UMR 8640 and LIA XiamENS).

Abstract

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Gold and carbon make it together: Gold nanoclusters (GNCs) impregnated onto reduced graphene oxide (RGO) nanosheets cross swiftly across HepG2 hepatocarcinoma cell membranes to alter proteins and DNA and transport anticancer molecular drugs, such as doxorubicin (DOX).

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