Advertisement

Scandium-Catalyzed Silylation of Aromatic C[BOND]H Bonds

Authors

  • Dr. Juzo Oyamada,

    1. Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    Search for more papers by this author
  • Dr. Masayoshi Nishiura,

    1. Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    Search for more papers by this author
  • Prof. Dr. Zhaomin Hou

    Corresponding author
    1. Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    • Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)
    Search for more papers by this author

  • This work was partly supported by a Grant-in-Aid for Scientific Research (S) from JSPS (No. 21225004).

Abstract

original image

Regioselective, hydrogen-acceptor-free C[BOND]H bond silylation of anisoles or alkoxy-substituted benzenes with hydrosilanes was achieved by use of a half-sandwich scandium catalyst. The reaction proceeds through ortho-C[BOND]H activation of an anisole compound by a scandium hydride species followed by the silylation of the resulting scandium 2-anisyl species with a hydrosilane (see scheme).

Ancillary