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Keywords:

  • antibodies;
  • bioorthogonal labeling;
  • host–guest systems;
  • nanoparticles;
  • supramolecular chemistry
Thumbnail image of graphical abstract

Be my guest: A supramolecular host–guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting.