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Keywords:

  • cyclodextrins;
  • desilylation;
  • protecting groups;
  • supramolecular chemistry;
  • synthetic methods
Thumbnail image of graphical abstract

A face off: Diisobutylaluminum hydride (DIBAL-H) has been found to be an effective O-desilylating reagent at the primary face of cyclodextrins. This methodology shows high chemo- and regioselectivity and provides an effective route to orthogonally protected, multisubstituted cyclodextrin derivatives.