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Keywords:

  • enantioselectivity;
  • hydrogenation;
  • iridium;
  • ligand effects;
  • synthetic methods
Thumbnail image of graphical abstract

Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.