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Keywords:

  • asymmetric catalysis;
  • N-heterocyclic carbene;
  • organocatalysis;
  • Stetter reaction;
  • synthetic methods
Thumbnail image of graphical abstract

New trick for an old cat.: Triazolium-based N-heterocyclic carbenes (NHCs) catalyze the selective generation of acyl anion equivalents for the title reaction. The stereoelectronic properties of the enal-derived Breslow intermediates and the unique reactivity of the modified chalcones are crucial for the Stetter reactions to occur. EWG=electron- withdrawing group.