1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/olbannercenter.gif?v=1&s=c083e1920cd41ed129901c116018eab93b5ad3c4)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Minireview
DNA Origami: The Art of Folding DNA
Article first published online: 7 DEC 2011
DOI: 10.1002/anie.201105846
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Saccà, B. and Niemeyer, C. M. (2012), DNA Origami: The Art of Folding DNA. Angew. Chem. Int. Ed., 51: 58–66. doi: 10.1002/anie.201105846
Publication History
- Issue published online: 29 DEC 2011
- Article first published online: 7 DEC 2011
- Manuscript Received: 18 AUG 2011
Funded by
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Alexander-von-Humboldt Stiftung
- European Union
- Max-Planck Society
- Abstract
- Article
- References
- Cited By
Keywords:
- design;
- DNA origami;
- DNA sequence design;
- nanostructures;
- self-assembly;
- supramolecuar chemistry
Abstract
The advent of DNA origami technology greatly simplified the design and construction of nanometer-sized DNA objects. The self-assembly of a DNA-origami structure is a straightforward process in which a long single-stranded scaffold (often from the phage M13mp18) is folded into basically any desired shape with the help of a multitude of short helper strands. This approach enables the ready generation of objects with an addressable surface area of a few thousand nm2 and with a single “pixel” resolution of about 6 nm. The process is rapid, puts low demands on experimental conditions, and delivers target products in high yields. These features make DNA origami the method of choice in structural DNA nanotechnology when two- and three-dimensional objects are desired. This Minireview summarizes recent advances in the design of DNA origami nanostructures, which open the door to numerous exciting applications.