We thank the Smith Family Foundation and Boston College for financial support. We also acknowledge the NSF (grant no DBI-0619576) for providing the financial support for the BC Mass Spectrometry Center.
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Communication
Stacked Fluoroaromatics as Supramolecular Synthons for Programming Protein Dimerization Specificity†
Article first published online: 21 NOV 2011
DOI: 10.1002/anie.201105857
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Pace, C. J., Zheng, H., Mylvaganam, R., Kim, D. and Gao, J. (2012), Stacked Fluoroaromatics as Supramolecular Synthons for Programming Protein Dimerization Specificity. Angew. Chem. Int. Ed., 51: 103–107. doi: 10.1002/anie.201105857
- †
Publication History
- Issue published online: 29 DEC 2011
- Article first published online: 21 NOV 2011
- Manuscript Received: 18 AUG 2011
Funded by
- Smith Family Foundation
- Boston College
- NSF. Grant Number: DBI-0619576
Keywords:
- dipole–dipole interactions;
- protein–protein interactions;
- self-assembly;
- stacking interactions;
- supramolecular chemistry
Aromatic “bonding”: Although known to exist in proteins, aromatic stacking interactions and the energetic factors important for it are not well understood. A systematic investigation of aromatic stacking interactions in a protein model system using a series of fluorinated phenylalanine analogues illustrates the importance of dipole–dipole and dipole–induced-dipole coupling to the stability and self-sorting properties of aromatic stacking pairs.