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Keywords:

  • dipole–dipole interactions;
  • protein–protein interactions;
  • self-assembly;
  • stacking interactions;
  • supramolecular chemistry
Thumbnail image of graphical abstract

Aromatic “bonding”: Although known to exist in proteins, aromatic stacking interactions and the energetic factors important for it are not well understood. A systematic investigation of aromatic stacking interactions in a protein model system using a series of fluorinated phenylalanine analogues illustrates the importance of dipole–dipole and dipole–induced-dipole coupling to the stability and self-sorting properties of aromatic stacking pairs.