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Keywords:

  • bioinformatics;
  • drug design;
  • interferon;
  • protein–protein interactions;
  • virtual screening
Thumbnail image of graphical abstract

Interfering with interferon: A low-molecular-weight inhibitor has been discovered that blocks the interaction between interferon-α (IFN-α) and its receptor (see picture for a model of the interfaces). The resulting lead compound significantly reduces IFN-α production in vitro. NMR and SPR experiments confirm the direct interaction of the inhibitor with IFN-α.